Posted on

Brain Computer Interfaces, Big-data, Machine Learning for Medtech and Edutech

The world is racing forward with medical technology- from neonatology to neurosurgery, new breakthroughs are making life more comfortable for people with disabilities. New medical devices are revolutionising healthcare, and these innovations will soon be incorporated into the standard of care. Here are three cutting-edge technologies that are making an incredible impact on both patients and physicians alike.

The first major medical innovation in recent years has been brain-computer interfaces; this technology allows people to control devices with their thoughts. Instead of pushing buttons or operating switches, disabled individuals can now browse through music or select programs on their televisions. Medical researchers have also created prosthetic hands controlled by neural implants. This allows disabled individuals to independently grasp objects while regaining lost dexterity. Computerized tomography (CT) scans can also create 3D models that patients can interact with through speech or gesture.

Another important medical breakthrough is big data- the analysis and interpretation of large quantities of information. Scientists use this data to conduct experiments and create analyses that inform their decisions. Big data is particularly useful in medical research because it enables scientists to study and analyze huge amounts of information in order to make discoveries. This has led to breakthroughs like genetic algorithms, which help computers make informed decisions in situations where humans can’t understand the full scope of the data.

One of the biggest challenges for developing technology is making it learn from mistakes and make improvements. This is what’s known as machine learning- a type of artificial intelligence used in robotics and other devices that learn from mistakes and make improvements. Military organizations use machine learning to create intelligent software for weapons systems and autonomous robots. The system learns by analyzing vast amounts of data and making decisions on the fly- which makes it perfect for military applications. Doctors use machine learning in biofeedback machines to help people with disabilities manage their symptoms, whether it’s stress or an asthma attack.

Advances in medical technology are bound to continue as new discoveries are made, large amounts of data are collected and analyzed, and disabled individuals can more easily access support systems. These innovations have the potential to transform modern healthcare; however, they’re currently being used by the medical community only a few generations away from disability status. As physicians become more accustomed to these new technologies, they’ll likely incorporate them into their treatment plans for physically and mentally challenged patients alike.

MedTech industry stats:

  • The global medical devices market size was estimated to be worth $447.63 billion in 2019. It is expected to grow to around $671.49 billion by 2027. (Precedence Research, 2020)
  • The market is expected to grow at a CAGR of 5.2% during the forecast period of 2020 to 2027. (Precedence Research, 2020)
  • Meanwhile, the medical devices market is expected to recover and grow at a CAGR of 6.1% from 2021, reaching $603.5 billion in 2023. (Precedence Research, 2020)
  • Analysis of the medical device market by country shows that the medical technology market size is dominated by North America, which accounts for about 39% of the pie. (Precedence Research, 2020)
  • In line with this, about 70% of the world’s largest original MedTech equipment manufacturers by revenue are headquartered in the US. (Brandon Gaille, 2020)
  • In 2019, the estimated total revenues of US and European medical technology companies amounted to $429.8 billion. (EY, 2020)
  • During the first half of 2020, the revenues of US MedTech enterprises saw a decline of about 5%, as many medical technologists were negatively affected by COVID-19. (EY, 2020)
  • Also in 2019, the non-imaging diagnostics segment recorded 12.2% revenue growth, while the therapeutic devices segment’s growth rate climbed to 12.5%. (EY, 2020)
  • Furthermore, the US telemedicine market valuation is expected to reach $25.88 billion by 2027. (Market Study Report, 2021)
  • Around 39% of senior executives in MedTech companies consider supply chain technology systems as a critical component of their operations. (Brandon Gaille, 2020)
  • Additionally, 43% of senior executives report that digitization of the supply chain is vital in their organization’s future success. Another 43% believe that big data is also a critical part of the supply chain. (Brandon Gaille, 2020)
  • Moreover, the MedTech industry, directly and indirectly, generates about two million jobs in the US. (Brandon Gaille, 2020)
  • At least 85% of health executives acknowledge that technology has become an inextricable part of the human experience. (Accenture, 2020)
Posted on

EEG test could enable early diagnosis of Alzheimer’s disease, innovative EEG test could diagnose Alzheimer’s disease 5  years earlier

Memory assessment: can be done by a volunteer without any prior training. 

A new memory assessment technique could pave the way for earlier diagnosis of Alzheimer’s disease, the underlying cause of around 60% of dementia cases. The approach uses electroencephalography (EEG) to measure brain activity while participants watch flashing images on a computer screen.

Current diagnostic tests for Alzheimer’s disease are not effective during its early stages, meaning that Alzheimer’s is typically only diagnosed late in the disease process. As such, there’s a real need for early diagnosis tools that could enable the timely initiation of lifestyle interventions to slow the rate of cognitive decline. Such a tool could also help drug development, through earlier and more accurate identification of dementia patients in clinical trials.

An EEG-based test may be developed that would decrease the age of diagnosis by up to five years in the near future. 

In the long term the EEG detection technique is known in the medical field but is not the only screening method recommended and has the potential to improve other methods.

 

The structure of a BCI system

EEG works by using multiple electrodes placed on the scalp (in an EEG cap) to record the brain’s electrical activity. BRAIN AI uses a method called fast periodic visual stimulation (FPVS), which measures brain signals as the subject views a series of rapidly presented images, a few of which are repeated at slower intervals. The technique is highly effective at picking up small, subtle changes in brain waves that occur when a person remembers an image.

The big advantage of BRAIN AI EEG Test is that it is completely passive. The person performing the test is not given any instructions prior to the task, which is important as dementia patients may struggle to follow complex instructions, and is not asked to reflect on, respond to or remember any items. The technique is also low-cost, non-invasive and uses technology that’s already available in hospitals.

BRAIN AI offers a genuinely novel way of measuring how our brain is functioning.

The person being assessed doesn’t need to understand the test, or even respond, they simply watch a screen of flashing images and by the way we manipulate the images that appear we can learn an enormous amount about what their brain is, or is not, able to do.”

The BRAIN AI procedure induces two discrete frequency responses in the EEG, which reflect the participant’s periodic neural responses to the stimuli. The first reflects visual processing at the image presentation frequency. The second mirrors the brain’s response to previously seen images and reflects the patient’s recognition memory. Analysing the EEG spectrum at this second, slower frequency can quantify the patient’s memory response.

BRAIN AI (EEG) testing could pave the way for improved outcomes for patients with Alzheimer’s disease by diagnosing the condition earlier, allowing treatments to be initiated before significant clinical signs appear. (surse: guidelines.co.uk)

Posted on

Major U.S. airlines warn 5G could ground some planes, wreak havoc and other health and technical problems

WASHINGTON, Jan 17 (Reuters) – The chief executives of major U.S. passenger and cargo carriers on Monday warned of an impending “catastrophic” aviation crisis in less than 36 hours, when AT&T (T.N) and Verizon (VZ.N) are set to deploy new 5G service.

The airlines warned the new C-Band 5G service set to begin on Wednesday could render a significant number of widebody aircraft unusable, “could potentially strand tens of thousands of Americans overseas” and cause “chaos” for U.S. flights.

“Unless our major hubs are cleared to fly, the vast majority of the traveling and shipping public will essentially be grounded,” wrote the chief executives of American Airlines (AAL.O), Delta Air Lines (DAL.N), United Airlines , Southwest Airlines (LUV.N) and others in a letter first reported by Reuters.

The Federal Aviation Administration (FAA) has warned that potential interference could affect sensitive airplane instruments such as altimeters and significantly hamper low-visibility operations.

“This means that on a day like yesterday, more than 1,100 flights and 100,000 passengers would be subjected to cancellations, diversions or delays,” the letter cautioned.

Airlines late on Monday were considering whether to begin canceling some international flights that are scheduled to arrive in the United States on Wednesday.

“With the proposed restrictions at selected airports, the transportation industry is preparing for some service disruption. We are optimistic that we can work across industries and with government to finalize solutions that safely mitigate as many schedule impacts as possible,” plane maker Boeing (BA.N) said on Monday.

Action is urgent, the airlines added in the letter also signed by UPS Airlines (UPS.N), Alaska Air (ALK.N), Atlas Air (AAWW.O), JetBlue Airways and FedEx Express (FDX.N). “To be blunt, the nation’s commerce will grind to a halt.”

The letter went to White House National Economic Council director Brian Deese, Transportation Secretary Pete Buttigieg, FAA Administrator Steve Dickson and Federal Communications Commission (FCC) Chairwoman Jessica Rosenworcel.

Airlines for America, the group that organized the letter, declined to comment. The FAA said it “will continue to ensure that the traveling public is safe as wireless companies deploy 5G. The FAA continues to work with the aviation industry and wireless companies to try to limit 5G-related flight delays and cancellations.” (source https://www.reuters.com/technology/exclusive-major-us-airline-ceos-urge-action-avoid-catastrophic-5g-flight-2022-01-17/ )

Posted on

The Social Dilemma – The Official Trailer – Cloud Breaking Big Tech Companies – Facebook, Google, YouTube, Twitter, Instagram etc.

Posted on

Charities Are Turning to Bitcoin Amid the Global Fight Against Coronavirus

In the war against the novel coronavirus, cryptocurrencies are emerging as a much-needed tool for charity and fundraising projects. Already there are a number of large nonprofits accepting Bitcoin donations. Plus, some blockchain and crypto firms are contributing medical supplies to hospitals in an attempt to curb the virus, while others are setting up fundraisers and charities that are aimed at helping its victims.
As a number of nonprofits continue to accept cryptocurrency donations, they are starting to realize that crypto transactions significantly reduce costs in terms of fees. Here are a number of charities and fundraisers that accept donations in crypto.
Red Cross
The rate of coronavirus infections in Italy is astonishingly high. For this reason, the Italian Red Cross moved to accept Bitcoin (BTC) and other crypto donations on March 12 with the goal of using the proceeds from the campaign to set up second-level advanced medical posts. The medical posts would be used to pre-triage coronavirus patients.
The project turned out to be such a success such that its fundraising goal of $10,710 was achieved by the third day of the campaign. Since then, the charitable organization has moved to raise even more funds through Bitcoin and other crypto donations with the goal of $26,000. The funds from the second round of funding are set to be used to buy emergency equipment. So far, the organization has achieved around 85% of its goal.
The Water Project
Apart from social distancing, one of the frequent calls by hygiene experts has been to wash hands. Without a doubt, hand washing is one of the crucial ways of fighting the spread of the coronavirus. Charitable organizations such as The Water Project have been at work installing and repairing water points all over impoverished regions in Africa. 
They have also been teaching communities how to wash hands and how to keep their water sources free from germs and other pathogens, as well as how to begin and maintain other good health practices. With coronavirus spreading through various countries in Africa, charitable organizations like The Water Project are crucial for the containment of the virus. 
For the first time, the organization has launched a fundraising project called WaSH — an acronym for water sanitation and hygiene — with the aim of raising funds to provide clean water and hygiene. Aside from standard methods of donation, the water project also accepts crypto donations in Bitcoin, Bitcoin Cash (BCH), Ether (ETH) and Litecoin (LTC).
— Citește pe cointelegraph.com/news/charities-are-turning-to-bitcoin-amid-the-global-fight-against-coronavirus

Posted on

Scientific sources: China Treating Coronavirus COVID-19 with Intravenous Vitamin C

 

Scientific source 1:

Source: https://stm.sciencemag.org/content/12/532/eaay8707

A vitamin boost for immunotherapy

Despite some controversy over the years, it is gradually becoming clear that vitamin C has some anticancer effects, albeit only when given intravenously and at sufficiently high doses. However, earlier studies evaluating the anticancer effects of vitamin C have used immunodeficient mice and therefore only examined its direct effects on tumors. By studying immunocompetent mouse models of cancer, Magri et al. determined that the vitamin’s effects were much stronger in the presence of an intact immune system and that it cooperated with checkpoint immunotherapy. These findings suggest a promising approach to combination treatment, which now needs to be tested in patients.

Abstract

Vitamin C (VitC) is known to directly impair cancer cell growth in preclinical models, but there is little clinical evidence on its antitumoral efficacy. In addition, whether and how VitC modulates anticancer immune responses is mostly unknown. Here, we show that a fully competent immune system is required to maximize the antiproliferative effect of VitC in breast, colorectal, melanoma, and pancreatic murine tumors. High-dose VitC modulates infiltration of the tumor microenvironment by cells of the immune system and delays cancer growth in a T cell–dependent manner. VitC not only enhances the cytotoxic activity of adoptively transferred CD8 T cells but also cooperates with immune checkpoint therapy (ICT) in several cancer types. Combination of VitC and ICT can be curative in models of mismatch repair–deficient tumors with high mutational burden. This work provides a rationale for clinical trials combining ICT with high doses of VitC.

 

 


Scientific Source 2:

Source: https://journal.chestnet.org/article/S0012-3692(16)62564-3/fulltext

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock

Background

The global burden of sepsis is estimated as 15 to 19 million cases annually, with a mortality rate approaching 60% in low-income countries.

Methods

In this retrospective before-after clinical study, we compared the outcome and clinical course of consecutive septic patients treated with intravenous vitamin C, hydrocortisone, and thiamine during a 7-month period (treatment group) with a control group treated in our ICU during the preceding 7 months. The primary outcome was hospital survival. A propensity score was generated to adjust the primary outcome.

Results

There were 47 patients in both treatment and control groups, with no significant differences in baseline characteristics between the two groups. The hospital mortality was 8.5% (4 of 47) in the treatment group compared with 40.4% (19 of 47) in the control group (P < .001). The propensity adjusted odds of mortality in the patients treated with the vitamin C protocol was 0.13 (95% CI, 0.04-0.48; P = .002). The Sepsis-Related Organ Failure Assessment score decreased in all patients in the treatment group, with none developing progressive organ failure. All patients in the treatment group were weaned off vasopressors, a mean of 18.3 ± 9.8 h after starting treatment with the vitamin C protocol. The mean duration of vasopressor use was 54.9 ± 28.4 h in the control group (P < .001).

Conclusions

Our results suggest that the early use of intravenous vitamin C, together with corticosteroids and thiamine, are effective in preventing progressive organ dysfunction, including acute kidney injury, and in reducing the mortality of patients with severe sepsis and septic shock. Additional studies are required to confirm these preliminary findings.

 


Why China Treating Coronavirus COVID-19 with Intravenous Vitamin C ?

Intravenous vitamin C is already being employed in China against COVID-19 coronavirus. I am receiving regular updates because I am part of the Medical and Scientific Advisory Board to the International Intravenous Vitamin C China Epidemic Medical Support Team. Its director is Richard Z. Cheng, MD, PhD; associate director is Hong Zhang, PhD.

Among other team members are Qi Chen, PhD (Associate Professor, Kansas University Medical School); Jeanne Drisko, MD (Professor, University of Kansas Medical School);

Thomas E. Levy, MD, JD; and Atsuo Yanagisawa, MD, PhD. (Professor, Kyorin University, Tokyo). To read the treatment protocol information in English: click this (Protocol in Chinese is here).

Direct report from China

OMNS Chinese edition editor Dr. Richard Cheng is reporting from China about the first approved study of 12,000 to 24,000 mg/day of vitamin C by IV. The doctor also specifically calls for immediate use of vitamin C for prevention of coronavirus (COVID-19). See this.

A second clinical trial of intravenous vitamin C was announced in China on Feb. 13th. In this second study, says Dr. Cheng,

“They plan to give 6,000 mg/day and 12,000 mg/day per day for moderate and severe cases. We are also communicating with other hospitals about starting more intravenous vitamin C clinical studies. We would like to see oral vitamin C included in these studies, as the oral forms can be applied to more patients and at home.” Additional information here.

And on Feb 21, 2020, announcement has been made of a third research trial now approved for intravenous vitamin C for COVID-19.

Dr. Cheng, who is a US board-certified specialist in anti-aging medicine, adds:

“Vitamin C is very promising for prevention, and especially important to treat dying patients when there is no better treatment. Over 2,000 people have died of the COIV-19 outbreak and yet I have not seen or heard large dose intravenous vitamin C being used in any of the cases. The current sole focus on vaccine and specific antiviral drugs for epidemics is misplaced.”

He adds that:

“Early and sufficiently large doses of intravenous vitamin C are critical. Vitamin C is not only a prototypical antioxidant, but also involved in virus killing and prevention of viral replication. The significance of large dose intravenous vitamin C is not just at antiviral level. It is acute respiratory distress syndrome (ARDS) that kills most people from coronaviral pandemics (SARS, MERS and now NCP). ARDS is a common final pathway leading to death.

“We therefore call for a worldwide discussion and debate on this topic.”

Source: 

https://www.globalresearch.ca/three-intravenous-vitamin-c-research-studies-approved-treating-covid-19/5705405